The antibodies react with conformational epitopes generated by factor XIII-induced linkage of the C-terminal appendages of the fibrin gam...Despite 50 years of clinical experience with vitamin K antagonists such as phenprocoumon or warfarin, many clinicians are uncertain how to start treatment, deal with overdose or bleeding complications, and how to bridge anticoagulation when treatment with vitamin K antagonists is interrupted. It is based on a chronic inflammatory process with infiltration and activation of leukocytes, and a rise in systemic inflammatory markers. The type of marker to be used has not been specified, but D-dimer antigen, or fibrin degradation products are used by most investigators. Currently, rFVIIa is approved for the treatment of patients with hemophilia with inhibitors to factors VIII and IX. Astonishingly, clinical trial and animal experimental data indicate that FVL can be associated with improved survival...Treatment with HMG-CoA reductase inhibitors (statins) reduces the morbidity and mortality of coronary artery disease (CAD). Wichtigstes diagnostisches Werkzeug hierzu ist die Gerinnungsanamnese. We aim to establish a new protocol for in-vitro coagulation to permit standardized sonothrombolysis investigations. - An interdisciplinary group of experts summarizes the state of knowledge of the use of rFVIIa in gastroenterology and hepatology, thrombocytopenia and -pathia, coa...D-dimer is an indicator for in vivo fibrin formation, reflecting the formation of fibrin crosslinked by factor XIIIa. The purpose of the present prospective study was to compare the clinical outcome of women and men presenting with ST-e...Platelets and monocytes play a pivotal role in the initiation and progression of large-vessel atherosclerosis. Although earlier studies have demonstrated postprandial activation of coagulation factors VII and XII, platelets and monocytes, conclusive evidence for intravascular fibrin formation afte...Rekombinanter Faktor VIIa (rFVIIa) wird über die zugelassenen Indikationen hinaus zunehmend zur Behandlung von lebensbedrohlichen Network. In this double-blind clinical trial, 47 patients with computed tomography (CT)-confirmed acute submassive PE treated with 1 mg...Increased platelet reactivity may contribute to the development of coronary artery disease and myocardial infarction. Conditions with increased thromboembolic risk, including trauma, extensive tissue damage...We present two children who developed a deficiency of factor XIII with valproate (VPA) treatment. Clinical syndromes associated with the condition are consum...The overt DIC score of the DIC subcommittee of the ISTH includes a fibrin-related marker (FRM) as indicator of intravascular fibrin formation. Blutungsereignissen bei Versagen der jeweiligen Standardtherapien eingesetzt. "Receptor Activator of Nuclear factor kappaB Ligand" (RANKL) and osteoprotegerin (OPG) are members of a cytokine system involved in bone turnover and vascular calcification.

Clinical trials with coagulation inhibitors have failed to show a significant benefit concerning survival. The percentage of organic search referrals to this site that come from this keyword.The percentage of all searches for this keyword that sent traffic to this websiteSimilar sites that share the same visitors and search keywords with this site.A relative level of audience overlap between this site and similar sites. Both patients showed recurrent epistaxis as major clinical sign of a combination of decreased coagulation param...- Recent studies have suggested that valvular calcification in calcific aortic stenosis (AS) may be actively regulated. Audience overlap score is calculated from an analysis of common visitors and/or search keywords.We don’t have enough data to display all the information typically shown here. An up-regulation of various platelet and coagulation activation markers has been described in cardiovascular diseases and in patients with acute cerebral ischemia. About. DIC is primarily a laboratory diagnosis, based on the combination of elevated fibrin-re...An abnormality of the optical transmission waveform obtained during measurement of the activated partial thromboplastin time (aPTT) has been described in association with overt disseminated intravascular coagulation. Eine Labordiagnostik sollte nur dann erfolgen, wenn aufgrund der sorgfältig durchgeführten Gerinnungsanamnese ein Verdacht auf eine Blutungsneigung besteht ode...The molecular basis of hypofibrinogenaemia was investigated in a 34-year-old woman and her 10-year-old daughter.

Publications. The aim of this study was to evaluate the thrombogenicity of sirolimus-eluting stents (SES) compared to bare metal stents (BMS) in a standardised in vitro model.

However, intravascular coagulation activation can occur despite normal INR values and is related to clinical events.

193. den Erkenntnisstand zu rFVIIa in der Gastroenterologie und Hepatologie, bei Thrombozytopenien und...Elevated markers of inflammation and coagulation are found in patients with coronary heart disease.

Initially...Disseminated intravascular coagulation in sepsis is associated with microvascular thrombosis and organ dysfunction. The clinical relevance of coagulopathies, known as side effects of VPA therapy, especially thrombocytopenia, von Willebrand disease, and a decrease of factor XIII, is still unclear.

Disseminated intravascular coagulation is defined as a typical disease condition with laboratory findings indicating massive coagulation activation and reduction in procoagulant capacity.

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